My journey with the lion's mane = Hericium and why you will (maybe) soon love it

I still remember it clearly: My introduction to the world of medicinal mushrooms began with Hericium erinaceus, the lion's mane mushroom. This white, feather-like structure looked so enchanting that I was truly impressed by it alone, not to mention its many different names, like monkey head mushroom, lion's mane mushroom, or hedgehog's mane mushroom.

When I tried it as a liquid extract, I noticed a delicate, almost creamy flavor with the sweet taste of glycerin, and after just a few days, something wonderful happened: My head became clearer, fatigue was suddenly no longer my constant companion, and my digestion? My bloating was instantly gone. Suddenly, this mushroom became more than just a trend; it became my friendly everyday companion.

Lionsmane - Löwenmähne - Hericium erinaceus - Igelstachelbart

Tradition meets everyday life, what culture knows about Hericium

The lion's mane mushroom has a long, traditional history in East Asia. It is not only edible, but also an integral part of traditional medicine. In China, Japan, and Korea, it served both as a nutritious delicacy and as a therapeutic agent.

He was particularly appreciated against chronic stomach problems such as gastritis or stomach ulcers, and as a tonic for mind and body.

In Traditional Chinese Medicine (TCM) it is used to strengthen the spleen and stomach, to harmonize the flow of Qi (mental clarity and digestive balance) and inner restlessness and nervousness It is also used to treat nervous disorders, increase vitality, and when one feels inner restlessness.

Today we also know: Studies indicate effects in the area of gastrointestinal health, anti-inflammatory and a possible connection with antitumor effects is even being investigated.

One thing remains clear: it is not a panacea. For serious illnesses, Hericium can be included in treatment plans as a complementary measure .

Between nerve cells, intestines and immune system: what research shows

1. Nerve cells & growth

Hericenone (from the fruiting body) and Erinacine (from the mycelium) promote the production of nerve growth factor (NGF) , and this molecule helps the brain to regenerate and grow.

Some animal studies and cell experiments show that these substances stimulate nerve cell growth, improve memory, and even trigger repair processes. Link to source>> Restorative Medicine Taylor & Francis Online Wiley Online Library Alzheimer's Drug Discovery Foundation PMC .

A small but impressive clinical study in Japan with people suffering from mild cognitive impairment showed cognitive improvements after 16 weeks of daily intake of lion's mane powder, but unfortunately these improvements declined after four weeks without intake, according to the Alzheimer's Drug Discovery Foundation .

Cell culture experiments have also shown that Erinacine A stimulates NGF production in human astrocytes (brain cells) Frontiers+15Frontiers+15ScienceDirect+15 .

2. Digestion, intestinal flora & inflammation

The stomach is receiving a lot of research attention: Hericium polysaccharides (HEPs) function like prebiotics: They promote the growth of beneficial intestinal bacteria and increase the production of short-chain fatty acids (SCFAs), which have anti-inflammatory effects Frontiers .

In animal models, HEPs also showed protective effects on the gastric mucosa, promoted the regeneration of damaged cells and strengthened the intestinal barrier MDPI .

3. Nerve regeneration & multiple sclerosis (MS)

In MS, the immune system attacks the myelin sheath of nerves, slowing nerve transmission. In experimental studies, Hericium was shown to be helpful by regenerating nerve fibers and activating cells that produce myelin. PMC+1 . The results are fascinating, but largely preclinical. Caution: No recommendation without medical supervision.

4. Mood, inflammation and immune system effects

A recent review (2025) highlights: Hericium has been shown to improve intestinal health , inflammation levels , promote BDNF (crucial for neurogenesis) and support depression, anxiety, eating disorders and sleep problems Frontiers .

Antioxidant and anti-inflammatory properties have also been demonstrated throughout the body, including potential protection against cell damage and chronic diseases Wikipédia+1 MDPI .

5. Against cancer?

In preclinical models, Hericium spp. water or ethanol extract significantly inhibited tumor growth, enhanced immune defenses, and reduced blood vessel formation in tumors, providing initial evidence of possible antitumor effects ( Alzheimer's Drug Discovery Foundation) . However, this is far from actual use in humans.

Moderation and observation – what we don’t (yet) know

• Much of the evidence comes from animal or cell model studies , good for a start, but not the end of the story.

• Human studies exist, but they are small and often pilot studies. Large, well-controlled studies are lacking, which only pharmaceutical companies can afford.

• Safety seems to be okay: Generally well-tolerated, with occasional mild stomach upsets. Be aware of interactions with medications or allergies. Alzheimer's Drug Discovery Foundation Wikipedia Frontiers .

• Suppliers vary widely, and quality matters. It's better to choose tested products.

Who is interested in the lion's mane mushroom?

• Those who want to experience a clearer head without stimulants.

• Those who suffer from mild inner restlessness.

• Anyone who wants to do good for their intestines with gentle, natural support.

• Anyone interested in nerve protection should use it as an accompaniment, not as a replacement.

• Anyone who is open to a treasure hunt between tradition, cuisine and research without promises of miracles.

Hericium erinaceus (Lion's Mane) potentials at a glance

• Cognitive health : NGF stimulation, nerve cell regeneration (hericenone, erinacine) Frontiers+8Restorative Medicine+8Alzheimer's Drug Discovery Foundation+8 .

• Memory & Focus : Clinical Improvement in Mild Memory Loss (16-Week Study) Alzheimer's Drug Discovery Foundation .

• Intestine & Digestion : Prebiotic effect, anti-inflammatory, protective effect on the gastric mucosa Frontiers MDPI ScienceDirect .

• Nerve regeneration : stimulation of myelin cells – relevant in autoimmune diseases such as MS Restorative Medicine PMC .

• Mood & Well-being : Positive effects on anxiety, depression, neurogenesis (BDNF) Frontiers .

• Antioxidant & immunomodulatory : reduction of inflammatory markers, activation of immune cells Wikipédia MDPI Alzheimer's Drug Discovery Foundation .

• Cancer research : Tumor-inhibiting effects in animal models, immune-supporting Alzheimer's Drug Discovery Foundation .

Conclusion: a look at Hericium erinaceus

The lion's mane mushroom is neither a magic potion nor a cure-all. Rather, it's a faithful everyday companion, quiet and gentle, with a rich cultural heritage. It has potential for the mind, stomach, and nerves, supporting you in subtle ways. For those who are curious and want to embark on a gentle but informed journey, this is a good sign. Step by step, with respect for tradition and an open mind.